The selectins, E-selectin and P-selectin on endothelium and L-selectin on leukocytes, bind specific ligands to promote rolling of leukocytes along the endothelial surface prior to vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1)-mediated tight binding and extravasation of leukocytes through endothelial cell junctions .

Detects human E‑Selectin/P‑Selectin (CD62E/P). Binds to COS cells transfected with human E-Selectin or human P-Selectin. It does not bind to CHO cells

There are 13 kinds of tags for each P-Selectin of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector. 1 reviews. Compare Anti-E-selectin Antibody Products from leading suppliers on Biocompare.

P selectin vs e selectin

Maximal expression of E-selectin occurs around 6–12 hours after cytokine stimulation, and levels returns to baseline within 24 hours. P- and E-selectin mediate CD4+ Th1 cell migration into the inflamed skin in a murine contact hypersensitivity model. In this model, not only CD4+ T cells but also CD8+ T cells infiltrate the inflamed skin, and the role of CD8+ type 1 cytotoxic T (Tc1) cells as effector cells has been demonstrated. Patients with VOC had higher levels of sP-selectin and sE-selectin compared to those in steady state (5.5 ± 4.6 ng/ml vs. 3.2 ± 0.8 ng/ml, t = 3.312, P = 0.001) and mean rank sE-selectin (53.2 vs. 35.8, MWU = 584.500, P = 0.001), respectively.

P-selectin are therefore functional under divergent conditions. Similarly to cell-surface P-selectin, E-selectin is rapidly down- regulated by internalization and degradation in lysosomes; however, the intracellular targeting mechanism of E-selectin is still unknown (63,72).

title = "Effects of E-selectin and P-selectin blockade on neutrophil sequestration in tissues and neutrophil oxidative burst in burned rats", abstract = "OBJECTIVE: Neutrophil deposition in tissues (leukosequestration) after shock may produce local tissue injury from proteases and high-energy oxygen species released from sequestered neutrophils.

1 reviews. Compare Anti-E-selectin Antibody Products from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and more. 1990-08-01 P-selectin and Congenital disorder of glycosylation type IIc · See more » Crizanlizumab.

av C Lonati · 2020 · Citerat av 1 — E-selectin and VCAM-1-positive vessels Melanocortins could reinforce endogenous signals providing protection versus respiratory Varga Z, Flammer AJ, Steiger P, Haberecker M, Andermatt R, Zinkernagel AS, et al.

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P-selectin is anchored in transmembrane region that is followed by a short cytoplasmic tail region. E-Selectin and P-Selectin are related (44% amino acid sequence identity) adhesion molecules containing multiple short complement-like repeats and an N-terminal C‑type lectin domain in their extracellular regions. E-Selectin is expressed on activated vascular endothelial cells and P-Selectin occurs on activated platelets and endothelial cells. Both E-and P-selectins are expressed on human arterial luminal endothelial cells of atherosclerotic plaques (195, 196), and mouse studies have shown that E-selectin and/or P-selectin deficiency substantially reduces the formation of atherosclerotic plaques, suggesting an overlapping function of these two selectins in the development of atherosclerotic lesions (197, 198). Combined, E‐selectin and P‐selectin mAb treatment inhibited T cell accumulation in all four types of reactions, and significantly more than E‐selectin blockade alone in migration to Con A. Results in E‐selectin‐ and P‐selectin‐deficient mice confirmed these observations, and demonstrated strain‐dependent differences in the contributions of the two selectins. 2018-08-02 · Moreover, whereas E-selectin is derived solely from endothelial cells, the other CAMs are derived from multiple sources such as platelets (P-selectin), leukocytes (ICAM-1) and cell types of non-vascular origin (VCAM-1), which may explain the strong association of E-selectin with aortic PWV .
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Simple Plex Cartridge Kit for 72 samples, containing E-Selectin for use with Human Plasma/Serum. Includes wash buffer and sample diluent. For use with the Ella automated immunoassay system.

E- and P-selectin as well as L-selectin are members of selec-tin family and members of a large group of adhesion molecules. They all exist in soluble forms in blood plasma, though each is synthesized or stored in different cells: E-selectin in endothelial cells, P-selectin in alpha granules of blood platelets and Weibel- E-selectin, as compared to L-selectin and P-selectin, is the redundancy of ligands through which it tethers PMN and executes a slow rolling immunosurveillance at velocities on the order of one micron per second. Another remarkable feature is that PMN rolling on E-selectin and subsequent ESL clustering transduce E-Selectin and P-Selectin are related (44% amino acid sequence identity) adhesion molecules containing multiple short complement-like repeats and an N-terminal C‑type lectin domain in their extracellular regions.
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Translations in context of "E-selectin" in English-German from Reverso Context: The use according to claim 35 wherein the carbohydrate moiety of said composition binds to L-selectin, E-selectin, or P-selectin.

3.2 ± 0.8 ng/ml, t = 3.312, P = 0.001) and mean rank sE-selectin (53.2 vs. 35.8, MWU = 584.500, P = 0.001), respectively. All binary logistic regression models were statistically significant.